The Royal Disease - Part I
It was a delightful sunny day when Leopold decided he would go play in the gardens of Buckingham Palace. Leopold was not just any old regular boy. He was a prince and son of Queen Victoria. As a young boy Leopold loved to play outside and he was a rather rambunctious individual. One problem with this lifestyle is the fact that it often led to poor Leopold getting hurt. Usually it was just a small cut or scrape, but these cuts never seemed to stop bleeding. Today Leopold was running around when he tripped and cut himself on a stray root. Running back to the palace crying, Leopold was assisted by some guards who brought him to the infirmary. From there the doctor’s attempted to get the bleeding to stop, however the blood continued to flow from the wound. Quickly this news spread throughout the palace and great concern grew among the people there.
Questions:
I. What is one reason that the bleeding would not stop? *Hint: Look at the case study title
II. a.) What is a gene?
b.) What is an allele?
c.) What is a sex-linked trait?
d.) Who is more likely to get hemophilia, males or females? Why?
III. Seeing as hemophilia is an x linked recessive disorder, consider the following:
a.) What would be the genotype of a hemophiliac male?
b.) What would be the genotype of a hemophiliac female?
IV. If a mother is a carrier for hemophilia and the father does not have hemophilia, could their daughter get hemophilia? Explain.
V. If neither of Leopold's parents have hemophilia, but Leopold does, what must the genotypes of his parents be? Use a punnett square to show your answer.
Questions:
I. What is one reason that the bleeding would not stop? *Hint: Look at the case study title
II. a.) What is a gene?
b.) What is an allele?
c.) What is a sex-linked trait?
d.) Who is more likely to get hemophilia, males or females? Why?
III. Seeing as hemophilia is an x linked recessive disorder, consider the following:
a.) What would be the genotype of a hemophiliac male?
b.) What would be the genotype of a hemophiliac female?
IV. If a mother is a carrier for hemophilia and the father does not have hemophilia, could their daughter get hemophilia? Explain.
V. If neither of Leopold's parents have hemophilia, but Leopold does, what must the genotypes of his parents be? Use a punnett square to show your answer.